IL-10 to TNFα Ratio: Strong predictor of rejection found in the blood.
A total of 244 kidney transplant recipients from the University of Pittsburgh School of Medicine participated in the study, 162 in the training set, and 82 in the internal validation set.
The investigators determined the ratio of interleukin-10 (IL-10) to tumor necrosis factor–α (TNFα) produced by transitional-1 B cells (T1B) in peripheral blood 3 months after transplant.
Their main goal was to see whether that ratio could serve as an early predictor of T-cell-mediated rejection (TCMR) in kidney transplant recipients. As the authors explain, B cells secrete IL-10 and TNFα. The ratio of these two molecules is a measure of regulatory B-cell activity, which has been implicated in organ rejection.
Source: Science Translational Medicine