Hormone therapy as a possible solution for postmenopausal women with nocturia.
A significant reduction in prevalence of nocturia ≥ twice per night was seen after treatment, as the prevalence decreased from 27.7% (59/213) to 16.4% (35/213). Specified per therapy, a significant reduction in nocturnal voiding frequency was observed in patients treated with E+P and TSEC (P = 0.018 and P = 0.018, respectively). This improvement could be explained by a significant reduction in SLEEP sum score in patients treated with E+P and TSEC (P < 0.001, P = 0.013, respectively). Estrogen-only led to a significant change in URINARY TRACT sum score, which is the result of a reduction in urgency prevalence (P = 0.039).
Estrogen + Progesterone (E+P), tissue-selective estrogen complex (TSEC) treatment led to a significant reduction in nocturia prevalence and bother in women with ≥ 2 nocturnal voids.
Source: Menopause Journal